Food allergies are on the rise
Sampath, V., Abrams, E. M., Adlou, B., Akdis, C., Akdis, M., Brough, H. A., Chan, S., Chatchatee, P., Chinthrajah, R. S., Cocco, R. R., Deschildre, A., Eigenmann, P., Galvan, C., Gupta, R., Hossny, E., Koplin, J. J., Lack, G., Levin, M., Shek, L. P., … Renz, H. (2021). Food allergy across the globe. In Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2021.10.018
, so there’s a growing need to reduce the risk of their development, and diagnose and manage them properly when avoiding them isn’t possible. It is estimated that 0.5% to 3% of one year old babies in developed countries have a cow’s milk allergy (CMA)
Flom, J. D., & Sicherer, S. H. (2019). Epidemiology of cow’s milk allergy. In Nutrients. https://doi.org/10.3390/nu11051051
. CMA can impact the healthy growth and development of infants and toddlers
Mehta, H., Groetch, M., & Wang, J. (2013). Growth and nutritional concerns in children with food allergy. In Current Opinion in Allergy and Clinical Immunology. https://doi.org/10.1097/ACI.0b013e328360949d
. Find out how milk protein hydrolysates can address this issue during this important period in life.
A food allergy is “an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food”
Boyce, J. A., Assa’ad, A., Burks, A. W., Jones, S. M., Sampson, H. A., Wood, R. A., Plaut, M., Cooper, S. F., Fenton, M. J., Arshad, S. H., Bahna, S. L., Beck, L. A., Byrd-Bredbenner, C., Camargo, C. A., Eichenfield, L., Furuta, G. T., Hanifin, J. M., Jones, C., Kraft, M., … Schwaninger, J. M. (2010) Guidelines for the diagnosis and management of food allergy in the United States: Summary of the NIAID-sponsored expert panel report. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2010.10.008
. CMA is one of the most frequently reported food allergies in infants and toddlers
Annesi-Maesano, I., Fleddermann, M., Hornef, M., von Mutius, E., Pabst, O., Schaubeck, M., & Fiocchi, A. (2021). Allergic diseases in infancy: I – Epidemiology and current interpretation. In World Allergy Organization Journal. https://doi.org/10.1016/j.waojou.2021.100591
. Sensitisation of the immune system towards milk protein can trigger adverse symptoms in allergic infants and toddlers upon secondary (repeated) exposure. Most children grow out of their allergy, but until then, our milk protein hydrolysates can help our customers support healthy growth in children that have a CMA.During hydrolysis, milk proteins are broken down into smaller components via an enzymatic reaction. Small peptides or amino acids are derived from intact proteins, which eliminates those proteins regarded as harmful by the immune system of infants suffering from CMA. These ingredients can be produced as partial or extensive hydrolysates, differing in the degree of hydrolysis and therefore peptide length. Extensive hydrolysates can be used in CMA or hypo-allergenic (HA) propositions, whereas partial hydrolysates can be used in HA formulas*. It has been suggested that when added to infant formula, partial hydrolysates may work to lower the risk of sensitisation of the immune system that could lead to allergy development
Vandenplas, Y. (2017). Prevention and management of cow’s milk allergy in non-exclusively breastfed infants. In Nutrients. https://doi.org/10.3390/nu9070731
. Extensive hydrolysates, on the other hand, are produced in such a way that they do not cause adverse symptoms when consumed by a child with existing CMA, while still supporting healthy growth.
During early life, infants can be susceptible to developing food allergies. Factors influencing this include family history, gender, ethnicity, pre-existing atopic dermatitis and genetic predisposition
Simon, A. K., Hollander, G. A., & McMichael, A. (2015). Evolution of the immune system in humans from infancy to old age. In Proceedings of the Royal Society B: Biological Sciences. https://doi.org/10.1098/rspb.2014.3085
, and the intestinal wall may be more permeable in early life, enhanced exposure to food allergens may occur during this time
Groschwitz, K. R., & Hogan, S. P. (2009). Intestinal barrier function: Molecular regulation and disease pathogenesis. In Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2009.05.038
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In these first years, a familiar pattern of allergy development has been recognized and is referred to as the ’allergic march’. The allergic march hypothesises how different allergies consecutively manifest over time. For example, it has been shown that atopic eczema and food allergy usually manifest during infancy, while asthma incidence peaks around the age of five and rhinitis as late as ten years of age (Barnetson, & Rogers, 2002). Because halting this pattern may benefit health later in life, CMA management in the early years is important.
Our new consumer research (Innova and RFC, 2020) reveals why allergies are a major priority for parents
Hydrolysates are proteins digested into smaller fragments, peptides, and its sole building blocks, the amino acids. So a hydrolysate is a blend of different peptides and different peptide lengths.
Hyvital® casein CMA 500 is an extensive hydrolyzed casein hydrolysate, with reduced allergenic properties and low lactose content.
Hyvital® casein HA 300 is a partially hydrolyzed casein hydrolysate, with reduced allergenic properties. This product is intended for formulas for infants with an increased risk to develop a cow’s milk protein allergy.
Hyvital® Wheat Glutamine PU is an enzymatically hydrolyzed wheat protein manufactured under carefully controlled conditions using food-grade enzymes.
Hyvital® Whey 8022 is a hydrolyzed whey protein concentrate with 80% protein content and a hydrolysis degree of 15%. It is specifically designed for sports nutrition applications as shakes and high protein bars.
Hyvital® whey CMA 500 is an extensive hydrolyzed whey hydrolysate, with reduced allergenic properties.
Hyvital® Whey EtD 100 is a partially hydrolysed whey protein hydrolysate suitable for use in Easy-to-Digest concepts. It has a long history of safe use and is designed to meet the most stringent quality requirements operational in Europe.
Hyvital Whey Easy-to-Digest 100 Organic is a predigested whey protein containing a spectrum of peptides and free amino acids. As a predigested protein it is ideally suited for use in comfort infant formulas.
Hyvital® Whey EtD 120 is a partially hydrolysed whey protein hydrolysate suitable for use in Easy-to-Digest products. It has a superior amino acid pattern and is designed to meet the most stringent quality requirements.
Hyvital® whey HA 300 is a partially hydrolyzed whey hydrolysate, with reduced allergenic properties. This product is intended for formulas for infants with an increased risk to develop a cow milk protein allergy.
As Nutri Whey™ Hydro is derived from fresh milk it has a clean, neutral flavor and aroma. Nutri Whey Hydro is a mildly hydrolyzed whey protein, containing di- and tripeptides and therefore faster digestible.
FrieslandCampina Ingredients is proud to play a global leadership role in the development of milk protein hydrolysates, backed by over 75 years of experience in ingredient manufacturing and research in early life nutrition. Discover how our milk protein hydrolysate solutions can help our customers support healthy growth in children with CMA.
* In EU, only if it complies to the annex of delegated regulation 2016/127
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